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Ee Research Group
Pharmaceutical Science Laboratory
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Ee Research Group
Pharmaceutical Science Laboratory
Our research programmes are categorised into three major topics
Rational Peptide Design
The primary sequence of a peptide defines its structure and activity. In our lab, we focus on the rational design of short antimicrobial peptides to create a library of therapeutic α-helices and β-hairpin peptides with multifunctionalities in mitigating infections. Our current focus is on controlling the higher-order self-assembly of β-hairpin peptides to form bacteria-specific nanonets. By systematically modifying side-strand sequences, we achieve precise control of nanofiber assembly on bacterial membranes, producing nanonets with distinct morphologies and functions. This approach allows us to target specific bacterial pathogenic mechanisms effectively. Future work is aimed at expanding the chemical space to enhance the multifunctionality of peptide nanonets and explore their potential for addressing complex infections.
Peptide in 3D matrices
3D matrices are transforming the way we study biological processes, providing a better representation of the complex environments in which cells, peptides, and other biomolecules interact. In our current research, we focus on understanding how peptides behave in a wide range of 3D environments, such as microbial extracellular polymeric substances (EPS) and hydrogels. We dive into exciting studies of peptide self-assembly and interactions with bacteria, breaking new grounds in our understanding of antimicrobial mechanisms and opening possibilities for novel therapeutic strategies. By developing these multi-functional 3D platforms, we aim to establish new use cases combining peptides and existing therapeutics for drug repurposing and therapy enhancement.
Peptide-Based Biomaterials
Peptide functionalization has emerged as a promising strategy in biomaterial development. Our lab focuses on developing peptide-functionalized biomaterials by integrating peptides into various materials to improve properties such as antimicrobial activity and biocompatibility. Our current research focuses on designing peptide coated biomaterials to address Catheter-Associated Urinary Tract Infections, aiming to reduce infection rates and improve healthcare outcomes. Previously, we have investigated crosslinked peptide-DNA nanostructures for wound dressing applications and peptide-conjugated CVD graphene for potential use in contact lenses. Additionally, we develop hydrogels as bio-inks for 3D bioprinting in regenerative medicine for targeted drug delivery. Overall, our work seeks to create peptide-based biomaterials that utilize the unique properties of peptides for infection control and therapeutic delivery.
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